웹2024년 8월 10일 · Analysis of BATF target gene expression along pseudotime revealed that the majority were induced early and ultimately repressed and included Aicda, Junb, Rela, … 웹Targeting BATF expression resulted in amelioration of the pathophysiologic responses seen in children with allergic asthma, and BATF has emerged as a novel target for antiasthma interventions. The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), ...
Ablation of BATF Alleviates Transplant Rejection - Frontiers
웹2024년 8월 15일 · At the molecular level, the A384T mutation altered Foxp3 interactions with its specific target genes including Batf by broadening its DNA-binding specificity. Our findings identify BATF as a critical regulator of tissue Treg cells and suggest that sequence-specific perturbations of Foxp3-DNA interactions can influence specific facets of Treg cell … 웹2024년 10월 29일 · Similar findings for loci encoding other Batf-target genes, including Ahr, Il23r, Il17a/f, and Maf further demonstrated that control of local chromatin accessibility by Batf is associated with modulation of gene transcription. Figure 3 Altered Chromatin Accessibility at Genomic Regions Containing Batf Target Genes. Show ... menashe sofer
Temporal regulation of gene expression during effector CD8 + T …
웹The cooperation of STAT3 with AP-1 transcription factors (e.g., BATF and IRF4) has been reported in B cells and CD4 + T cells (Ciofani et al., 2012;Kwon et al., 2009;Xu et al., 2024). It is ... 웹2024년 4월 4일 · BATF plays a key role in the differentiation of T helper cell subsets and Ig class-switching. ... Hence, the previous findings on BATF make it an interesting target for the treatment of Th cell-derived-cytokine-driven diseases. Retinoic acid signaling and BATF productions are activated in IgAN patients compared with controls. 웹Objective: The basic leucine zipper transcription factor, ATF-like (BATF), a member of the Activator protein-1 family, promotes transcriptional activation or repression, depending on … mena shetty facebook