WebLupus-like disease in BAFF transgenic mice BAFF-BCMA interactions are required for the survival of long-lived plasma cells [128], whereas B-cell memory is independent of BAFF/APRIL signaling. BAFF transgenic mice develop hypergammaglobulinemia, autoantibodies, glomerulonephritis, and destruction of the salivary glands [137, 140]. WebJan 20, 2011 · A BCMA agonistic antibody also enhanced CpG-induced proliferation, activation, and IgG secretion by B cells in both healthy controls and lupus patients. Furthermore, the agonistic BCMA antibody co-stimulated auto-antibody production by CpG-stimulated lupus B cells in vitro.
Elranatamab, a BCMA-targeted T-cell redirecting immunotherapy, …
WebJul 30, 2009 · The homologous molecule APRIL binds to TACI and BCMA but not to BAFF-R. TACI is activated by multimerized or membrane-bound BAFF and multimerized APRIL, but not by homotrimers. BCMA is a high-affinity receptor for APRIL; in humans BCMA binds BAFF with low affinity, whereas mouse BCMA is APRIL-specific (reviewed in [ 24 ]). Seventeen SLE patients were included in a prospective study to evaluate changes in soluble BAFF, APRIL and BCMA levels and associate these changes with clinical manifestations (Supplementary Table). Patients received standard-of-care therapy according to disease manifestations evaluated during clinic visits … See more The general characteristics and primary demographics of all enrolled participants including 129 SLE patients (123 females and six males) and 34 healthy controls … See more BCMA receptor expression was decreased in the CD19+ B cells of SLE patients compared with those of HCs (median: 0.5% vs 13.10%, respectively; p < 0.01) … See more The level of the decoy receptor sBCMA was elevated in SLE patients (49.03 ng/mL) compared with HCs (25.60 ng/mL; p < 0.05) (Fig. 1J). The levels of the … See more As shown in Fig. 2B, sBAFF had a modest correlation (rs = 0.2537) with disease activity, while both sAPRIL (rs = 0.4952) and sBCMA (rs = 0.6177) showed a … See more difference between registration and trademark
Breaking the ice in systemic lupus erythematosus: …
WebDec 5, 2024 · Recently, three members of the BAFF family (BAFF, APRIL and soluble BCMA) have been assessed in the same cohort of SLE patients to evaluate their … WebJul 26, 2024 · Biological: BCMA-CD19 cCAR T cells. Phase 1. Detailed Description: Systemic lupus erythematous (SLE) is a chronic diffuse connective tissue disease … WebThe Lupus Foundation of America has a national network of local chapters that can provide a list of physicians in their service area who diagnose and treat lupus. Need help … form 41 schedule d alabama