Camptothecin mw

Author: hbft

August undefined, 2024

WebCamptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian … WebMolecular Weight (MW) 348.35 Formula C20H16N2O4 CAS No. 7689-03-4 Synonyms N/A 2 years -20°C Powder 2 weeks4°C in DMSO 6 months-80°C in DMSO Solubility (25°C) …

Structures of Camptothecin (1, MW 348) and its analogues

WebCamptothecin, Camptotheca acuminata - CAS 2114454. BRD-A30437061-001-01-9. BRD-A30437061-001-04-3. Q27163449. 4-Ethyl-4-hydroxy-1H,12H-6,12a-diaza-2-oxa-13H-dibenzo [b,h]fluorene-3,13 (4H) … WebApr 13, 2024 · The fabrication of pH-sensitive lignin-based materials has received considerable attention in various fields, such as biomass refining, pharmaceuticals, and detecting techniques. However, the pH-sensitive mechanism of these materials is usually depending on the hydroxyl or carboxyl content in the lignin structure, which hinders the … great lakes whaleback

Structures of Camptothecin (1, MW 348) and its analogues

WebHerein, we fabricated a novel amphiphilic lactose-camptothecin prodrug molecular Lac-SS-CPT which can self-assemble into Lac-SS-CPT glyco-nano prodrug system for GSH responsive and targeted drug co-delivery due to the existence of disulfide bond and lactose. 41–44 Then, the CPT-based glyco-nano prodrug system further provides a suitable ... WebSep 11, 2007 · Camptothecin demonstrated strong anticancer activity in preliminary clinical trials but also low solubility and adverse drug reaction. Camptothecin is believed to be a … Camptothecin (CPT) is a topoisomerase inhibitor. It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used in traditional Chinese medicine. It has been used clinically more recently in China for the tr… flock of sheep talk back

(S)-(+)-Camptothecin = 90 HPLC, powder 7689-03-4 - Sigma-Aldrich

Camptothecin mw

Camptothecin- and etoposide-induced apoptosis in human …

WebCamptothecin is a topo I poison that both inhibits enzyme activity and stabilizes formation of topo I cleavage complexes (Hsiang et al J. Biol. Chem. 260:14873-14878, 1985). TopoGEN provides this reagent as a control inhibitor/poison of topoisomerase I. For in vitro cleavage detection, we recommend that the drug be tested in the range 100 uM ... WebMin: 1. Step: 1. Add to Cart. TG2011-4. Topoisomerase I Western Blot Marker. The Western blot marker set for topo I is used to unambiguously locate the position of the 100 kDa form of intact topo I. This product is supplied in SDS-PAGE loading buffer and ready to load directly onto an SDS-PAGE. $ 375.00. Max:

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WebCamptothecin is an alkaloid compound used as an anti-cancer agent. It is a topoisomerase I inhibitor in DNA synthesis. Camptothecin has been shown to bind and stabilize a topoisomerase I-DNA complex in vitro, preventing … WebCamptothecin. Camptothecin is a naturally occurring alkaloid derived from the plant Camptotheca acuminata that was identified in an anticancer drug discovery screen in the 1960s.67 Camptothecin forms a stable ternary complex, preventing normal DNA re-ligation, and causes the complex to collide with the replication fork, leading to a DNA double …

WebCamptothecin, an quinolone alkaloid, is used as a chemotherapeutic agent in the treatment of leukemia (Jones et al., 1997). Camptothecin complexes with type I DNA … WebCamptothecin traps an important cellular enzyme, topoisomerase I, in complexes with DNA. This prevents cancer cell DNA replication and results in the death of the cancer cell. This unique mode of action rekindled interest in developing analogs of camptothecin that were both water soluble and retained anticancer activity.

WebAug 21, 2009 · Human serum was spiked with camptothecin and the sample injected in a mixture of 250 μl each of upper and lower layer. Fig. 8 depicts the chromatogram of this run. As an extracted ion chromatogram at m/z = 349 shows, camptothecin, of MW 348, elutes at 37.9 min, or nearly identical to its elution time from dog bile. In this solvent system, the ... WebCamptothecin is a natural product extracted from the bark of the tree Camptotheca acuminata. Topoisomerase-I is a nuclear enzyme that relieves torsional strain in DNA by opening single strand breaks. [16] Once topoisomerase-I creates a single strand break, the DNA can rotate in front of the advancing replication fork.

WebCamptothecin showed best apoptosis at 12uM concentration which is equal to 4ug/ml of your working concentration. I calculated it as follows: Camptothecin MW= 348.36 4ug/ml= 4mg/L 4mg/L/348.35...

WebCamptothecin; 9-Nitro-20 (S) Camptothecin (Rubitecan) 10-Hydroxy Camptothecin; 9-Amino Camptothecin; Topo II. Doxorubicin (Adriacin) Daunomycin; Etoposide (VP16) Amsacrine (m-AMSA) Genistein; Ellipticine; HU-331; Gyrase & Topo IV. Ciprofloxacin; Cell Context DNA Repair. Homologous Recombination Reporter Cells. Human: HeLa … flock of sheep planterWebCamptothecin (CPT), a proven anticancer drug, is distributed across several families and genera and is still extracted from Nothapoytes foetida and Camptotheca acuminata, due to their initial discovery in these two plants. The study of biogenesis and chemistry of CPT is imperative, as this paves a way for semisynthesis or total synthesis of CPT. flock of shoebillsWeb位置：首页 > 产品库 > 7-Ethyl-d3-camptothecin. 7-Ethyl-d3-camptothecin. ... 分子量 Molecular Weight: 379: 闪点 FP: 409.1±32.9 ℃ ... great lakes whaleback freightersWebApr 10, 2024 · The virtual screening revealed that two alkaloidal metabolites, camptothecin and GKK1032A2 showed excellent binding energy with any target proteins compared to reference commercial fungicides, Azoxystrobin and Strobilurin. ... The molecular weight of the selected compounds was more or less than 500 g/mol (348.35 g/mol and 503.67 … great lakes west senecaWebCamptothecin, Camptotheca acuminata A cell-permeable DNA topoisomerase I inhibitor.; CAS Number: 7689-03-4; Synonyms: Camptothecin, Camptotheca acuminata,4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione; find Sigma-Aldrich-208925 MSDS, related peer-reviewed papers, technical documents, similar … flock of sheep walking in circleWebCamptothecin, Camptotheca acuminata. Synonym (s): Camptothecin, Camptotheca acuminata. Empirical Formula (Hill Notation): C20H16N2O4. CAS No.: 7689-03-4. Molecular Weight: 348.35. Compare. Product No. flock of sheep walking in circle for 12 daysWeb84 MW. Fuel Resource . Photovoltaic Solar. Ownership. Southern Power. Southern Power, a subsidiary of Southern Company, is a leading U.S. wholesale energy provider meeting … flock of snowbirds