High-affinity choline uptake protein bett

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August undefined, 2024

Webmax of 80 nmol/min/mg of protein) for choline transport relative to other known BCCTs. Although BetT activity increased in response to hyperosmolarity, BetT mediated signiﬁcant uptake under low ... WebGene ID: 13909447, discontinued on 16-Jul-2024. Summary Other designations. High-affinity choline uptake protein BetT

Membrane topology and mutational analysis of the osmotically …

WebMeyer EM, Cooper JR (1983) High affinity choline uptake and calcium-dependent acetylcholine release in proteoliposomes derived from rat cortical synaptosomes. J … WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. … open source thin client windows

Choline Uptake - an overview ScienceDirect Topics

WebThe initial step in the CDP-choline/Kennedy pathway is uptake of choline into cells by three classes of transporters: the high-affinity (K D 2 μM), sodium-coupled choline transporter 1 (CHT1 or SLC5A7); intermediate-affinity (K D 10–100 μM), sodium-independent choline transporter-like (CTL) proteins of the SLC44A family; and low … WebCholine uptake is regulated by nerve impulses and trafficking of an intracellular pool of CHT1 to the plasma membrane may be important for this regulation. We have generated a hemagglutinin (HA) epitope tagged CHT1 to investigate the organelles involved with intracellular trafficking of this protein. Expression of CHT1-HA in HEK 293 cells ... WebCholine uptake High affinity Na+-dependent Synaptosomes Certain basic characteristics of choline uptake in nerve terminals were ... protein, 0,567 uM [3H]-choline (final concentration), for 20 min at 371. The KM value of [3H]-choline uptake was 2.27+0.26 10 20 30 40 Time (min) 60 B I ipay rockwell

High-affinity transport of choline-O-sulfate and its use as a ...

Web29 de jul. de 2014 · The high-affinity choline uptake activity was also shown to depend on the kind of anions and on the concentrations of K +: the highest activity was observed in the presence of Cl − and 0.35–4.8 mM K +, together with 126 mM Na + . Selective distribution and characterization of the high-affinity choline uptake system in cholinergic neurons WebIn cholinergic neurons, high-affinity choline uptake in presynaptic terminals is the rate-limiting step in acetylcholine synthesis. Using information provided by the … ipay registration instructionsWeb1 de jan. de 2024 · The high-affinity choline uptake activity in patients with these diseases was predicted to be diminished by mutations that impaired CHT1 function and/or trafficking. There is a functionally relevant, nonsynonymous single nucleotide polymorphism in the coding region of the human CHT1 gene (c.265A>G, rs1013940) (Okuda et al. 2002 ). open source threat intelligence github

"Web27 de fev. de 2015 · Only strains FB24 and A6 contained both the choline binding protein A gene and high-affinity choline uptake protein (BetT) gene; only strains M2012083, TC1, Sphe3 and Rue61a contained the choline ... " - High-affinity choline uptake protein bett

High-affinity choline uptake protein bett

Expression of the high-affinity choline transporter CHT1 in epithelia

WebCHT1 protein is mainly found in intracellular organelles, such as endosomal compartments and synaptic vesicles. The presence of CHT1 at the plasma membrane is limited by … Web5 de mai. de 2024 · The high-affinity choline transporter CHT1 mediates choline uptake, the rate-limiting and regulatory step in acetylcholine synthesis at cholinergic presynaptic …

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WebA choline uptake system with a high affinity for choline has long been assumed to be present in cholinergic neurons. Very recently, the molecular entity for the high-affinity … WebCholine uptake (Vmax) increases up to 3 months of age and decreases significantly from 1 to 7 years of age ( Fig. 6A; Table III ). A further indication of a reduced synthesis with …

Web3 de mar. de 2024 · The betT gene encodes the high-affinity choline uptake protein BetT, betI encodes the choline-responsive BetI repressor for both choline uptake and betaine synthesis (Scholz et al. 2016), and opuA is … WebIn addition to the industrial and biomedical applications of lithium, information on the tolerance of microorganisms to high Li concentrations in natural biological systems is limited. Strain LCHXa is a novel free-living Gram-positive, non-motile

WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. … WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. Proteomes. Protein sets from fully sequenced genomes. Annotation systems. Systems used to automatically annotate proteins with high accuracy: UniRule (Expertly curated rules)

WebThe uptake of choline can occur via two transport systems, one that exhibits a high affinity for choline uptake (HAChU, K m =1–5 μM) and is dependent on both Na + and Cl −, and a second transporter system that has a significantly lower affinity for choline uptake (LAChU, K m =10–100 μM) and is independent of Na + and Cl − (see also Ch. 3).

WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. … ipayroll christchurchWeb10 de jun. de 2005 · In cholinergic neurons, the synthesis of acetylcholine (ACh) depends upon the reuptake of choline from the synaptic cleft by a high-affinity, sodium-dependent hemicholinium-3 (HC-3)-sensitive transporter (Haga 1971; Yamamura and Snyder 1972, 1973).Choline uptake is the limiting step for ACh synthesis, with increased choline … ipayroll downloadWebIn cholinergic neurons, high-affinity choline uptake in presynaptic terminals is the rate-limiting step in acetylcholine synthesis. Using information provided by the Caenorhabditis elegans Genome ... open source threat intelligence platformsWeb1 de mai. de 2008 · This transporter has a particularly low affinity (Km of 876 μM) and high capacity (Vmax of 80 nmol/min/mg of protein) for choline transport relative to other … open source threat intelligence apiWeb8 de mar. de 2006 · The high-affinity choline transporter at the molecular level. Despite the fact that the high-affinity choline uptake system was described in the 1960s, the genes for the high-affinity choline transporter proteins (CHT1) of Caenorhabditis elegans and rat have only recently been cloned (Okuda et al. 2000). ipayroll feesWeb8 de nov. de 2005 · The choline uptake activity is completely inhibited by the protonophore carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP). 1 publication … open source threat report pdfWeb23 de dez. de 2009 · We identified a choline, betaine and carnitine transporter, designated Cbc, from Pseudomonas syringae and Pseudomonas aeruginosa that is unusual among members of the ATP-binding cassette (ABC) transporter family in its use of multiple periplasmic substrate-binding proteins (SBPs) that are highly specific for their … open source threat intel